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Katie: Hey and welcome to “The Wellness Mama Podcast.” I’m Katie from wellnessmama.com and wellnesse.com, that’s wellness with an E on the tip. And I’m right here at present with my buddy, Naveen, who’s an intensely curious entrepreneur who has been taking over some huge, audacious concepts to push humanity ahead. He’s the creator of the award-winning e-book “Moonshots: Making a World of Abundance,” and his present moonshot adventures are Viome and Moon Categorical, which is an area firm. However as a serial entrepreneur, he’s additionally based InfoSpace, Intelius, and Expertise Clever, amongst others.
And his present work is in Viome Life Sciences, which was based in 2016 with a mission of constructing sickness non-compulsory by predicting and stopping persistent illness by means of a deeper understanding of a person’s biology at a molecular degree. And it’s constructed on an AI-driven platform that analyzes the interplay between meals, our microbiome, and our human selves to develop precision suggestions to forestall and reverse persistent illness. He’s additionally the vice-chairman of the board at Singularity College, and on the board of XPRIZE Basis. He’s been the recipient of many issues together with Entrepreneur of the Yr, Most Inventive Individual by Quick Firm, Prime 20 Entrepreneurs, and lots of extra.
On this episode, we discuss in regards to the human ecosystem and customized optimization of your intestine well being and your general well being. We discuss in regards to the cause the intestine impacts your entire physique. Why it’s not simply genetics from our dad and mom however really our ecosystem inside our intestine that controls our physique. Why 70% of the immune system is within the intestine. How microbiome stability begins at start and even earlier than. How 90% of serotonin is produced within the intestine, not the mind. What makes up the ecosystem of the intestine. We get fairly granular on this one.
The distinction between DNA and gene expression. How some meals may be good for some folks and never others, and the best way to know which is finest for you, but in addition, the universally dangerous meals. Why there are some universality dangerous ones however not universally good ones. Why he doesn’t suggest harsh merchandise that kill micro organism within the mouth or within the intestine. The true cause it’s vital to chew your meals rather well earlier than swallowing, and a lot extra. Lot’s of sensible information on this episode. Additionally, a lot of hyperlinks to be taught extra within the present notes at wellnessmama.fm, so test these out. However with out additional ado, let’s be a part of Naveen Jain. Naveen, welcome again.
Naveen: Properly, Katie, so good to see you lastly after an extended, very long time.
Katie: I’m so excited we get to have a dialog and get to report it and share it at present, and we’re gonna discuss lots about intestine well being and even past intestine well being, how this impacts the well being of the entire physique. Earlier than we do, although, I might say you’re the one individual I do know in actual life who has a Moon rock assortment. And so, I might love so that you can simply discuss this as a result of I believe you’re my solely hobbyist Moon rock collector.
Naveen: Properly, I believe, Katie, you realize, to me, the Moon is symbolic. It’s symbolic of what humanity is able to doing. So, to me, going to the Moon is a means of expressing that there’s nothing that’s not possible for us to do. Regardless that it’s referred to as “Moonshots” that individuals thought was tough, if not not possible to do and having, you realize, now to have the ability to go to the Moon and to me, the gathering of house rocks really was simply merely a interest of in a position to maintain one thing in your hand. Which may be even earlier than the start of our planet. And it offers you some thought of how fragile we’re that if we don’t handle ourselves, our planet, we as humanity could not survive. As a species, we could not survive.
So, you realize, thought of when somebody says, “I’m actually apprehensive about our planet,” ask the planet and planet will let you know, “Don’t you are worried about me as a result of we…” Planet will just do effective however human species could not survive. Similar to dinosaurs. And to me, having a Moon rock merely jogs my memory that all of us are linked collectively. When one thing exterior us goes flawed, we as inner ecosystem can even be impacted, proper. And that’s coming right down to, you realize, when you take a look at what’s above, so under is basically what’s exterior the ecosystem and the universe impacts us, and our ecosystem inside us impacts the universe.
Katie: I really like that you simply mentioned it like that as a result of I interviewed my oldest son on this podcast a pair hundred episodes in the past when he launched a cookbook and you realize him as properly. And I requested him that query. You recognize, your technology’s gonna face lots within the environmental and local weather stuff. And, I raised this query and he goes, “Properly, mother, you’re really asking the flawed query as a result of the…”
Naveen: Oh, I like it, I like it.
Katie: He mentioned, “The planet is a self-correcting organism. It’s gonna heal itself. It’s only a query of whether or not we get to remain right here when it does. And we must be asking how we may be extra synergistic inside an surroundings that’s larger than us.”
Naveen: That’s the excellent reply. That’s precisely how I might see it that…you realize, when folks say, “Aren’t you apprehensive in regards to the planet?” I say, “That’s not the query you have to be asking.” It’s, “Are we apprehensive in regards to the human species?” That’s what we ought to be asking.
Katie: Which is an ideal segue as a result of that’s one thing that you’re intimately concerned with and I might say not apprehensive about however working to resolve. My listeners are fairly well being savvy and perceive or a minimum of have a passing understanding that intestine well being impacts the entire whole physique. However I really feel like this idea is…properly, we’ve identified points of it for a very long time. We’re seeing a lot extra analysis about it proper now. And we’re…due to corporations like Viome, we’ve many extra tangible instruments to really perceive and begin to do one thing about that. However to start out broad, form of give us an summary of what we imply by the well being of the intestine impacts the well being of the entire physique.
Naveen: So, properly, to begin with, you realize, let’s simply begin from the start. We as human beings usually are not merely a product of the DNA from our mother and pop. What we’re is a symbiotic ecosystem, and in that ecosystem, 99% of all of the genes which might be really expressed in our human physique usually are not our personal. They arrive from these microbes which might be in our mouth, in our intestine, throughout us. So, think about…I imply, there’s actually…if we take a look at the human beings as such by way of all of the genes which might be expressed that makes us who we’re, they don’t seem to be people. They’re largely microbial. We’re dwelling of their world. They don’t dwell in our world, proper.
So, after we perceive that, you realize, despite the fact that you possibly can argue that they’re the puppet masters and we’re merely the host or puppet for his or her profit, and you possibly can argue sometime that perhaps they really created us to unfold them round, perhaps they created us to allow them to rule the world, proper, however in all honesty, we coevolved collectively. In coevolution what occurs is we feed them and we give them a pleasant and heat and cozy place to remain. In flip, they feed us the vitamins that our physique wants to really be wholesome, proper. So, think about from the time a child is born, and I believe that is one thing that most individuals don’t notice, that within the first couple of days of mom’s breast milk is stuffed with oligosaccharides. And that can’t be digested by the human physique. That’s there just for the microbes within the intestine to have the ability to convert into vitamins. Meaning it’s to create the ecosystem inside us.
Now think about what nature is telling us, that we simply created a offspring and one of the best ways to maintain this offspring wholesome is to not feed it however to feed them who’re going to maintain the offspring wholesome. And because the child goes by means of the start canal, that is the primary publicity the child will get to the entire world of microbiome. It will get…utterly inhales the microbiome because the child’s going by means of start canal. And sadly, a few of the moms for apparent causes find yourself getting a C-section. They really…the infants usually are not going by means of the identical…they’re uncovered to pores and skin microbiome fairly by means of the start canal, the microbiome that they’d get by means of the start canal. And that could be a essentially…the child, when it’s born, is definitely…the character has created in a means that the microbes get launched into the child on the time of the start and that truly now turns into a coevolution course of. And the mom’s breast milk begins to feed these microbes to create this ecosystem.
And because the intestine microbiome begins to get wholesome, it begins to coach our immune system. And I believe that is the basic half that individuals want to know. Seventy p.c of our immune system is alongside our intestine lining. In actual fact, all of the analysis exhibits that how intestine microbiome is continually coaching our immune system what’s a buddy and what’s a foe, proper. So, in some sense, when you take a look at the human physique, there’s a tube that goes by means of us. There’s a prime of the tube in your mouth after which there’s the underside of the tube, and you then begin to have a look at all alongside the traces there’s a large quantity of microbial existence there. They usually the truth is are always interacting with our immune system and the immune system is now understanding when there’s really a pathogen that’s coming by means of the meals or the pathogen that’s coming by means of the skin world, the best way to react to it. And these microbes are the primary sign that tells the immune programs, “This isn’t good. Go do one thing about it, proper.”
And I believe to me, that symbiotic relationship breaks down when there’s a dysbiosis within the intestine. So, I believe as your son identified, not simply the planet however even the human physique is designed to heal itself. The human physique is designed to be in homeostasis. And any time…and whether or not we lower our pores and skin or whether or not there’s some kind of pathogen or we get some kind of a illness, it usually is designed to heal itself if our physique is in stability. So, when there are intestine microbial actions and the human host are always in sync and wholesome and our immune system is wholesome, then our physique will really heal itself. When there’s a dysbiosis or imbalance of the intestine microbiome, that is the place the unease occurs. When your physique will not be comfortable, you get illness which we name illness.
Katie: Yeah, so many vital factors you simply mentioned to unpack. And I believe the primary being that we actually are extra bacterial than human and also you…right here you mentioned you’re what you eat but it surely goes up to now past that. It’s not even you’re what you eat and even you’re what you eat-eat, however what your intestine micro organism eats and the way it grows. And I really like that you simply introduced up the start canal factor as a result of I’m a doula and I’ve really helped in a number of C-section births with feeding the child, as a result of such as you mentioned, when you don’t…the child is of course meant to seed their intestine by means of the start canal. And if that doesn’t occur, such as you mentioned, they’re seeding to the hospital room, to pores and skin, to probably disinfectants which might be in that room, every kind of issues. And we all know that this intestine micro organism at start, increasingly we be taught, units you up to your complete life. But in addition, the excellent news is…and I do know that Viome does a whole lot of analysis on this. All will not be misplaced when you don’t get an ideal begin. We now have the flexibility to form of get a snapshot and look within the intestine in a very distinctive means after which optimize to enhance somebody’s well being going ahead.
And in addition, such as you mentioned, the physique’s pure state is well being. It’s not typically that we have to do something drastic. We have to get out of our personal means and simply take away the issues which might be conserving the physique from being wholesome or perhaps generally give it little additional vitamins to assist get there. Discuss slightly bit in regards to the science of Viome and what we’re testing as a result of this expertise didn’t even exist a pair many years in the past, and now we’ve such superb knowledge from this.
Naveen: Properly, it’s very fascinating is this concept of, you realize…when you return and take a look at couple of many years in the past, it was really the micro organism and all these organisms have been thought-about as an enemy of the human physique. That’s the minute you see them, your job is to kill them as shortly as potential as a result of they will’t presumably be there for our good, proper. And as we began to be taught extra in regards to the human physique, we realized that the majority of those organisms are literally commensal. They’re speculated to be there and so they the truth is…after we feed them issues like, you realize…in olden days, after we have been dwelling within the savannas of Africa, we’ll pull out a leaf or we’ll pull out the foundation and eat it. That’s stuffed with fiber. These fibers are literally what our intestine microbes eat, and people intestine microbes, by consuming these fibers, really flip them into brief chain fatty acids. Issues like butyric, issues like acetate, these have been all of the vitamins that our physique wanted.
In actual fact, when you begin to consider it, 90% of all of the serotonin is definitely produced in our intestine, not in our mind. So, when you actually take into consideration all of the issues which might be being performed within the intestine and the way what occurs within the intestine doesn’t merely keep within the intestine, it really impacts the entire physique together with our mind to coming again to it, Katie, that you simply identified. What occurs in our intestine impacts our temper. So, whether or not it’s a melancholy or nervousness or, you realize, you may name them any names you need, you realize, lots of these items together with autism is now linked instantly into the intestine microbiome. In actual fact, they’ve performed now the analysis the place they did merely a microbial transplant referred to as a fecal transplant and so they have been in a position to the truth is present that children with autism, their autistic signs went down by 50% even after two years simply by merely doing the microbial transplant. They have been in a position to present once you took an individual that has a melancholy a microbial transplant or nervousness, it may be transferred just by transferring the microbiome into one other species. They usually’ve performed them in mice and so they’ve performed that the truth is in people, and clearly, it was performed by mistake however that’s really the way it occurred.
In actual fact, what’s actually fascinating is dependancy. They usually’ve proven the identical factor. They took…there have been 17 folks on the analysis that have been utterly hooked on alcohol. And people folks, they gave them a fecal transplant from individuals who really had no dependancy. And these folks’s dependancy went away. Now think about that, that our intestine microbiome are controlling our mind by way of what to do. That’s what the dependancy is, proper. And I believe that’s actually phenomenal.
And now what we’re studying is each kind of most cancers…the truth is what they’ve now checked out is each single strong tumor has microbes inside that tumor. Take into consideration {that a} second, the microbes are contained in the tumor. And what we discovered most fascinating was there’s microbial peptides being displayed on the floor of the tumor. Now, why would a tumor that’s an organism eager to survive would ever show a microbial peptide except it’s there to idiot our immune system into pondering that is self and protects the tumor towards the immune system attacking, proper?
Now, think about what…one other factor that’s most fascinating I discovered was once you do immunotherapy, it really works about one-third of the time. And the folks the place the immunotherapy doesn’t work, within the 70% of the those that immunotherapy didn’t work, they merely have been in a position to do a change of their intestine microbiome and the identical immunotherapy began working. So, our intestine microbiome will not be solely there to maintain us wholesome from all of the ailments at present we name the completely different names. Coronary heart ailments, it’s coming from our intestine microbes really producing issues like trimethylamine or TMA. TMA will get absorbed within the blood and our liver converts them into TMAO, trimethylamine oxide. In actual fact, we are able to now take a look at issues like LDL manufacturing which is a foul ldl cholesterol manufacturing and see how microbial actions and microbial metabolites really change the LDL manufacturing. You’re ready to have a look at how…what’s taking place in your intestine, how are we altering the inflammatory markers in our host. So, we’re in a position to measure the intestine exercise and the human host exercise, all their cytokines. So, we’re each interleukins, we’re the entire inflammatory markers to see how they’re altering with the intestine microbial exercise.
And so, anyway, the purpose I’m attempting to make is that you simply talked about one thing about these micro organism, and I simply need folks to know the microorganisms usually are not simply micro organism. They’re predominantly micro organism however additionally they encompass yeast, viruses and even the RNA viruses or fungus or mildew. All of these items are literally the entire ecosystem and the most important half the truth is when you observed virtually 10 to 1 if no more is definitely phages. And phages are the viruses that infect the micro organism. And when you take a look at any nature whether or not you’re trying within the swamp otherwise you’re trying on the intestine microbiome, the truth is there are 10 instances extra phages than the micro organism alone. And meaning these viruses that infect micro organism are modifying the bacterial…the organism, the capabilities of those micro organism that the truth is adjustments how these micro organism behave by way of what capabilities they’re performing.
So once more, what’s actually fascinating is by what organisms are there, won’t ever let you know what’s going on in your physique. In actual fact, their capabilities are what makes the distinction. Meaning what they’re producing can…is basically the one factor that issues what these intestine microbes are producing, not who they’re. And I believe, Katie, you in all probability know that a whole lot of the folks like Akkermansia muciniphila. A number of the corporations are promoting them as a probiotic with out realizing that Akkermansia may be good for some folks and in reality it’s the primary cause for inflicting a number of sclerosis, and it has additionally been instantly linked to Alzheimer’s, proper. So now give it some thought. The identical organism can do one thing good for one individual and might do one thing actually dangerous in one other individual. So, taking one thing blindly, taking any complement, any probiotic, any prebiotic blindly is definitely not good for you as a result of your physique is totally completely different than different individual’s physique. The identical organism or similar probiotic may be good for somebody and could possibly be dangerous for an additional individual. And that’s the most important studying we’ve had within the final six years.
Katie: Yeah, I really like that you simply introduced up the fecal microbiota switch as properly. I’ve seen a few of the science on this and… you realize, caveat, this isn’t one thing to aim at house but it surely’s fairly superb what they’re engaging in in labs with some actually focused and really particular methods of doing that. And I really feel like in a way, that is additionally one thing you may accomplish with out having to go to that excessive if you realize what you’re working with. And for the final two years, I’ve been saying, you realize, early on in well being and wellness, I might discover out data, learn research and be so excited and write about it, and I’ve realized increasingly over the past 15 years all the pieces is so customized and so individualized. And so now when folks ask me like, “What precisely did you do to reverse your Hashimoto’s?” I say, “You recognize, I can let you know what I did but it surely’s not gonna work the identical for you. It may be an thought with the place to begin but it surely’s not gonna be your blueprint. Every of our blueprints is gonna be very, very completely different.”
Which is why I really like now increasingly entry to those at-home testing whether or not it’s issues like Viome, even now blood testing accessible at house, genetic testing simply so we are able to have extra data and entry. And I’ve mentioned so many instances on right here we’re every our personal major healthcare supplier. On the finish of the day, it’s nice to work with docs however we’re every our personal major healthcare supplier. And I really feel like having instruments in our pocket that permit us be more practical at that may actually, actually make a distinction. So, let’s discuss slightly bit extra in regards to the personalization facet of this as a result of I additionally am curious…you realize, I do know you mentioned all the pieces is so completely different. What’s good for one individual is perhaps not for an additional. Are there any issues which might be form of universally dangerous that you simply’re discovering in Viome? Like, I might put perhaps processed vegetable oils on the don’t cross checklist, however I’m curious what you’re seeing within the knowledge.
Naveen: Yeah. So to begin with, it’s actually fascinating. I believe you phrased it appropriately. There isn’t a such factor as common wholesome meals. And meaning there isn’t any such factor that’s good for everybody. Meaning the identical meals may be good for you or dangerous for somebody. Nonetheless, there are some common unhealthy issues you can know. So, there isn’t any common wholesome factor however there are universally unhealthy issues. Sugar is a type of unhealthy issues. There isn’t a one who says, “The sugar is sweet for me, proper.” In order that’s really having a fried, you realize, fried meals. So, all fried stuff, it’s simply dangerous for everybody. Consuming a whole lot of sugar, it’s simply dangerous for everybody. Nonetheless, what we discover most fascinating is that analyzing the human physique and analyzing primarily based on what’s going on and what’s dynamically altering in your physique…and I believe a whole lot of the people who find themselves listening to it, I would like folks to know the distinction between a DNA which is static. So when folks do their DNA take a look at, it tells you what’s inherently there in your physique. It doesn’t let you know what is definitely occurring in your physique. Meaning…if, Katie, you enable me, I’m gonna clarify the DNA as a result of I believe to me lots of people get very confused about what DNA is.
So, each a part of our physique is an identical DNA. Meaning you take a look at my hair, you take a look at my eyes, you take a look at my tooth, you take a look at my nails, you take a look at my finger, it’s precisely the identical DNA. Then why is it we don’t have the eyes rising on my fingers and the nails rising on my head? Similar DNA. And the reply is there’s…when some genes are overexpressed, some genes are below expressed, the identical DNA can develop into eye, similar DNA can develop into nail, similar DNA can develop into pores and skin, similar DNA can develop into coronary heart cells or neurons or issues like that, proper. So, level is DNA is like an alphabet and the story you’re writing is definitely what’s being expressed. It’s referred to as RNA. So, RNA tells you the story that’s being written for you proper now and DNA tells you each potential factor that may occur. And that’s one factor.
So, what we do at Viome, Katie, is we take a look at your gene expression and what gene expression tells us is what story your intestine microbes are writing. What story your human host is writing. And now I’m gonna come again and let you know…some information to share with you in the direction of the tip. As soon as we perceive all that’s occurring, we’re in a position to then let you know, “Hey, don’t eat broccoli or cabbage as a result of your sulfide manufacturing in your intestine is just too excessive and the sulfide want sulfates to supply sulfide and the broccoli and cabbage are very excessive in sulfate so you need to lower it down, proper.”
We are able to let you know that…lots of people will let you know go take vitamin B3. However vitamin B3’s really not good for you when you could have excessive uric acid manufacturing. So don’t take vitamin B3 when you have excessive uric acid manufacturing. Equally, everybody will let you know, “Hey, take curcumin and turmeric. It’s actually good anti-inflammatory.” It’s. Nonetheless, when your bile acid manufacturing may be very excessive, you don’t need to take curcumin as a result of it’s going to transform into bile salt that’s gonna trigger extra irritation. Lots of people assume by some means taking NAD or NR, and NMN which is precursor to NAD is definitely enhance your longevity. It’s true for some folks it could do this, however for others it really will hurt you when you could have excessive mobile senescence, or when you could have excessive inflammatory exercise. You don’t need to be taking further NAD as a result of that’s gonna enhance the mitochondrial biogenesis that’s going to extend extra free radicals, gonna enhance excessive mobile senescence, proper.
So, the thought actually is that you must be taught what is going on earlier than you deal with your physique like a black field. And I believe you’ve mentioned it proper, that we’re simply…we’re the CEO of our personal well being. We’re those who have to know what is going on in our physique as a result of our major care physician…I don’t learn about you, Katie. Once I go to my major care physician, by the point I begin talking, he’s already writing the prescription. I imply, actually, the phrase he says… “Oh, did you say coughing? Right here it’s. Did you say this? Give me the in poor health, I’ll provide the tablet.” And that’s all they’re merely doing. They don’t have to…they don’t care to know what’s inflicting that to occur in my physique. Like, you had Hashimoto, or when you had any kind of an autoimmune illness, the very first thing they let you know is simply take the immune suppression medication and suppress the symptom. Not fear about what’s inflicting it, and that could be a elementary drawback that our healthcare system has is that our medical industrial advanced, everybody makes cash after we are sick and nobody makes cash after we are wholesome. And so, we determined to alter that. In my world of the long run, Katie, we consider that…I believe identical to you simply mentioned, the way forward for healthcare goes to be delivered at house, not on the hospitals.
And the medicines of the long run are gonna come from a farm, not a pharmacy. And that’s going to be the most important change you’ll begin to see us taking management of our personal well being. And I believe COVID has been one of many…I might say when you look again at COVID 10 years from now, it will likely be the most important inflection level that occurred in humanity’s notion of that we as people have management our personal actions and our actions have well being penalties.
Katie: Completely. I believe so many good silver linings and instructing moments in COVID and folks spent extra time at house and with their households cooking dinner at house. There have been a whole lot of nice outcomes, as onerous because it was for many individuals. I believe we are able to give attention to these positives. And I really like your rationalization of DNA and the way it goes past simply your genetics. It’s about how they’re expressed and the way that’s managed within the intestine. And I’d like to go slightly bit deeper about Viome as a result of I do know I talked to you years in the past about this and also you guys have made some huge advances since then. So, discuss form of the snapshot of what Viome is testing after which how individuals are making adjustments primarily based on that and what they’re seeing.
Naveen: Sure. So clearly, Katie, a few years in the past we did a intestine intelligence chart that merely measured your intestine well being. After which we realized that that was actually good but it surely didn’t inform us how these intestine adjustments have been impacting us and the human physique. And so, we now launched…about two years in the past throughout COVID really, we launched our well being intelligence take a look at that measures your blood and it measures your stool, and by doing the finger prick blood, so that you don’t should go to a lab. It’s a easy finger prick blood, couple of drops of your blood. And your starch of your stool. We’re in a position to now take a look at each your intestine well being and your human host and in a position to now let you know what’s your organic age. And that tells you not solely, you realize, how properly or how poorly your physique is growing older in comparison with your chronological age.
So, to offer you an thought, I’m now gonna be 63 in September and my organic age is right down to 50. And that tells you that actually that my physique is performing on the degree once I was 50. And I really feel it. I run up the steps two stairs at a time and I’ve extra vitality than the truth is I had once I was 50. And that merely tells you what your organic age is. Then we provide you with immune well being. Meaning how properly are you protected towards when you have been to catch flu or chilly or any kind of pathogen, how properly your physique is ready to shield itself? And that’s your immune well being. Your mobile well being. That tells you the way properly your cells are in a position to endure the issues which might be occurring within the human physique. Mitochondrial well being, that’s your vitality manufacturing unit. How properly the mitochondrial well being is performing as a result of if it’s not, you get mind fog, you’re feeling fatigued, you’re feeling drained. We provide you with clearly your intestine well being.
And now that is one thing new that we’re gonna be launching in June and we’re launching a brand new product referred to as full physique intelligence. And for the primary time, we’re gonna be analyzing all the best way from prime of your tube, your saliva, your stool and blood, all three on the similar time. And by that, we’re additionally gonna have the ability to present you some further insights comparable to your coronary heart and metabolic well being. We’re gonna be supplying you with your mind and cognitive well being. We’re gonna have the ability to present you your oral well being comparable to your gum well being, your tooth well being and all of the gum, you realize…leaky gum as a substitute of simply leaky intestine. We’ll have the ability to present you the way properly your boundaries of your gums are performing in order that microbes usually are not going into your blood.
And different factor we do now which we didn’t do till a few yr in the past is once you do a take a look at, not solely you get your deep perception what’s taking place in your physique and never simply let you know listed here are the meals which might be good for you and right here is why. Listed below are the meals you need to keep away from and why. We used to let you know listed here are the dietary supplements you need to take. Now we transcend that, Katie. We’re in a position to let you know you solely want 22 milligram of berberine daily. You want 17 milligram of elderberry daily. You want 79 milligram amylase daily. And we undergo each vitamin, minerals, herbs, meals extracts, digestive enzymes, amino acids, probiotics, prebiotics, and we actually make these for you on demand.
There isn’t a premade stuff. Consider it like a compounding pharmacy. There are robotics compounding pharmacy. It says, these capsules are being made for Katie. Go to bin quantity 17, get 17 milligram of elderberry. Go to bin quantity 29, get 27 milligram of berberine. And we actually take all of the strawberry extract right here, put this factor right here. And by the best way, as soon as we get the powder, we make the capsules and ship them off to you each month. And as your physique adjustments, we modify your dietary supplements on the similar time. So, each time you retest, we are saying, “Oh, you don’t want amylase anymore. What you actually need is butyrate now,” proper. And we actually are in a position to alter your…as your physique is altering, we adapt the diet that your physique wants. And people are the brand new issues that I’m tremendous enthusiastic about.
Different issues that I’m actually, actually enthusiastic about…and we’ve not talked to anybody but about it. We’re gonna be launching in June additionally our most cancers detect. And that is gonna…first time as a shopper you’ll have the ability to spit in a tube and with 95% specificity and 90% sensitivity, we’ll have the ability to let you know when you have any oral most cancers or throat most cancers. After which we’ll have the ability to really join you with a health care provider to have the ability to do one thing about it. So, in case you are above…over 50 years previous or have any historical past of smoking, vaping, chewing tobacco, you’ll have the ability to really at house do a take a look at and truly know that you simply’re not at a threat of growing a most cancers proper now. Otherwise you’re growing a most cancers proper now.
Katie: Yeah. That is so innovative and I believe simply to focus on what you mentioned, that is actually fascinating information of principally machine studying and AI and this adaptive expertise. And since you’ve now examined 1000’s and 1000’s, in all probability a whole bunch of 1000’s of individuals, then the algorithm has entry to all this data so it will possibly proceed to get increasingly specialised and direct with the suggestions and be taught your personal physique over time. So, you’re getting this sort of ongoing, correct image which I believe is so fascinating.
Naveen: Yeah. So, Katie, we’ve analyzed over 350,000 samples already. And that has given us this…you realize, the a part of being the…a part of that Viome ecosystem is each single one that joins profit from the opposite 350,000 samples that we’ve analyzed and so they contribute to the ecosystem, and our AI and machine studying is continually getting higher. And for each single one that joins profit themselves and advantages the humanity on the similar time as a result of now the extra we be taught, the higher suggestions we are able to make for everybody. So, earlier than we simply solely may take a look at your stool. Now we take a look at stool plus blood. Now it’s stool plus blood plus saliva. And we’re gonna launch…the subsequent factor might be with urine. After which we’re gonna begin to have a look at different biomarkers in your physique. So, our suggestions get increasingly exact as we be taught increasingly in regards to the human physique. And our actual hope is, you realize, in my lifetime we’ll have the ability to perceive what causes the onset of a persistent illness and what causes them to progress and to have the ability to forestall them from taking place within the first place, to diagnose them early after they really do occur, and to give you a remedy for these ailments. Not merely handle them however to remedy them as soon as for all for every particular person. And that’s going to be the last word aim of our life.
Katie: And I really like that you simply introduced up the interplay of all of the completely different microbiomes throughout the physique as properly and the way you’re all of those, as a result of a few of my early analysis was in oral well being and studying as an example that strep mutants and the micro organism that trigger gingivitis don’t each exist on the similar time. And it is because we’ve an oral microbiome. And if it will get out of stability in a single path or the opposite, you’re gonna find yourself with these issues. However the reply will not be sterilizing your mouth and killing all micro organism identical to we wouldn’t need to within the intestine. It’s getting a wholesome oral microbiome that has that ecosystem that it wants. Similar factor with the intestine. And such as you mentioned, you’re these all through the entire physique. I do know your daughter’s additionally doing a little fascinating analysis with the vaginal microbiome and I’m excited to talk along with her about that.
However I believe, like we talked about at first, since our physique is extra bacterial than human, the extra we perceive about these interactions, the extra form of intricate knowledge we are able to get to make enhancements over time and naturally there could be a most cancers connection right here. You recognize, I’ve heard it mentioned that most cancers is a metabolic illness in some half. And it is a means of…as a result of even inside a person, when you’re a metabolic illness, you’re , “Okay, we have to get blood sugar in test. We have to get blood stress in test. We have to get weight problems measures in test.” However the best way to try this’s gonna be completely different for each single individual.
Naveen: I believe it’s a metabolic and inflammatory illness. So, I imply, it’s prompted…persistent irritation is a root reason behind persistent ailments. Nonetheless, what causes the irritation in our physique is completely different for every particular person. So despite the fact that it’s the irritation which may be on the root trigger however the underlying causes for that irritation are very, very completely different. And as you talked about, our daughter is, you realize…has this firm referred to as Evvy, E-V-V-Y, which seems to be on the vaginal microbiome. And to me, what she’s doing is so phenomenal and particularly your viewers, each single girl ought to do this as a result of that’s actually…goes to be…you realize, a lot of ladies undergo by means of lots of the ailments that we as males would by no means perceive. And that to some extent is, you realize, largely reproductive organ and lots of the instances the later analysis exhibits that vaginal microbiome is concerned in preterm start, within the well being of the child and all of the issues that you simply talked about because the child goes by means of the start canal. All of the issues that come out the truth is are contributory from the vaginal microbiome. So, my excessive advice…once more, I’m biased. I believe each girl ought to be doing the Evvy take a look at, proper.
Now, coming again to the stuff you talked about that, you realize, human well being is advanced however as soon as we perceive biochemical degree what’s going on, that’s the rationale as a substitute of organisms and as a substitute of DNA, we targeted on the gene expression or RNA. We targeted on what microbes are producing. Trying on the complete physique. And I believe, Katie, I wanna level out that the merchandise that you simply construct for oral well being are a few of the finest merchandise as a result of, to me, what’s the greatest gamechanger is folks thought the organisms have been your enemy. So, they’ve this Listerine. Kills 99% of all of the micro organism in your mouth. For heaven’s sake, don’t do this. Once you kill the ecosystem in your mouth, it really destroys the entire digestive tract. And I wanna simply emphasize, you realize, to folks when our moms informed us to chew our meals, she didn’t ask us to chew the meals as a result of they thought the meals was too huge to go down our esophagus, proper. It was really was once you chew your meals, you’re permitting the oral microbiome in your saliva to really predigest the meals, and by predigesting the meals…along with predigesting, it additionally sends the sign to the intestine and to the physique about what’s coming down. So, when it tastes candy, it begins to launch the sign for pancreas to launch the insulin, as a result of it is aware of the candy stuff is coming down.
So, the primary factor is that we have to enable the oral microbiome to predigest the feed so your small gut can now soak up the vitamins which might be already predigested. So, if you end up…so two issues you want to take into consideration right here. And one is if you end up harassed and you’re consuming your meals, it doesn’t get correctly digested and right here is why. When you’re harassed, you’re in a combat or flight response. And the primary factor that occurs once you’re in combat or flight response is your digestive system shuts down. Bear in mind why it was designed. Once you’re operating away from a tiger, at the moment, the physique knew there isn’t any level worrying about digesting your meals as a result of both you’re gonna be lunch for another person otherwise you’re going to outlive. And when you turned lunch for another person, it didn’t matter. And when you survive, guess what? The stress went down and also you moved from sympathetic mode to parasympathetic mode and you possibly can digest your meals.
Once you come from work and you’re harassed, what will we inform folks? Earlier than you eat, do the gratitude. Why is that? It’s since you need to convey your physique from sympathetic mode into parasympathetic mode. Eliminate combat or flight response. By taking the deep breath, by doing the gratitude, what you’re doing is definitely permitting your physique to have the ability to be able to digest the meals. Then once you chew your meals, you’re permitting your saliva and oral microbiome to really predigest your meals. And these are easy methods we discovered within the historic tradition however we now know scientifically why did they are saying that, proper. We inform…like, Katie, you could not know that my mother and pop and our faith, they don’t eat after sundown. And I all the time marvel why would that be. And it seems as a result of you want to have three or 4 hours of break after you eat meals earlier than you fall asleep. So, they made that as a faith don’t eat after sundown so as a result of folks will get three, 4 hours of digestion. So, the truth is telling that, you realize…and that to me was actually the factor that we discovered as a part of our tradition. Really, seems we’re very scientific.
And I wanna come again to the oral merchandise. I believe folks must be actually enthusiastic about oral microbiome well being and utilizing the precise oral toothpaste, oral issues that…you realize, probiotics. And the merchandise, a few of the merchandise that you’ve, Katie, are designed to reinforce your oral well being and oral microbial actions or oral microbial ecosystem in your mouth. And I believe everybody who’s listening to it to start out concentrate as a result of that’s the primary. Your mouth really is the start of your digestive tract. It’s not merely a gap to your digestive tract. It’s the path of the digestive tract the place the digestion occurs.
Katie: I completely agree. I believe very multifaceted however begin with the mouth is so vital. And I really like a few the stuff you simply talked about about why we don’t digest meals if we’re harassed and we all know, in fact, that Individuals dwell in a persistent state of stress typically. And one factor I’ve develop into keen on…you realize, there’s a cause many cultures additionally pray or meditate proper earlier than consuming, which additionally helps the physique get into parasympathetic or you may merely do respiration workouts. Do some field respiration to calm your nervous system. I really like that your loved ones naturally from a spiritual perspective stopped consuming at sundown. I’ve discovered in my very own life that I do nice once I time restricted eat and for a very long time I might wait and never eat until midday after which eat later within the day. And I observed once I shifted that to consuming and stopping by sundown, I really feel so significantly better and it goes to that time you talked about about letting your physique end digesting earlier than you sleep in order that once you’re sleeping, you may be therapeutic and your physique can get into autophagy and you may allocate sources to all of the pure processes the physique has in-built to maintain us wholesome.
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And I additionally wanna piggyback on what you mentioned about the identical cause we don’t wanna kill our oral microbiome is similar cause we don’t wanna kill our intestine micro organism as properly however I nonetheless see folks form of hopping on the bandwagon of those actually harsh cleanses or in fact folks generally take antibiotics for causes whether or not they should or not. And people can each have a fairly harsh impression on the intestine. And so, I’d love to speak about it. Possibly if somebody is aware of they’ve been on antibiotics earlier than or they know they’ve a intestine concern associated to actually form of killing a few of these good micro organism. Clearly, Viome helps with this however form of, like, what may be performed? How can we assist repair it?
Naveen: So, very first thing is, you realize, earlier than you go begin taking a whole lot of issues is to know, what’s the state of your intestine micro organism? So do a Viome take a look at, perceive the place it stands. And you then begin to have a look at what you…you realize, we let you know what are the meals you need to eat. And once more, taking a whole lot of the fermented meals particularly once you’re attempting to repopulate or rebootilate your intestine microbiome, actually the issues ought to be diversification. So as a substitute of simply taking one kind of probiotics, you have to be taking kombucha, the kimchi, the…you realize, all of the fermented meals you may presumably get your fingers on. So, whether or not it’s a yogurt or, you realize, a minimum of oat milk yogurt when you can. I imply, I’m an enormous fan that I believe dairy…the truth is for lots of the folks, dairy is the massive drawback. Now I’m not saying it’s for everybody however a whole lot of the folks, dairy could possibly be an enormous drawback. And the mammalian merchandise really could possibly be an enormous drawback for some folks and never for others.
So, I’m not the one who is preaching veganism right here in any respect. What I’m saying is know what is sweet for you. There are lots of people who can eat purple meat for all of their life and dwell to be 100, and the rationale for that’s purple meat incorporates clearly as you all know, choline and carnitine that may get transformed by our intestine microbiome into issues like TMA. And I discussed TMA is the one which will get absorbed within the blood, causes the TMAO which causes the guts illness. So, it’s not the purple meat that causes the guts illness. It’s the byproduct of how the purple meat is digested in some those that produce TMA. So, in case your TMA manufacturing is low, you need to eat purple meat if you wish to as a result of it’s not gonna hurt you. And that’s actually the purpose is to know, don’t merely ban meals and complete class of meals.
One other factor that we discovered…we printed a paper having analyzed over 100,000 folks at the moment on growing older. And what we discovered, Katie, that you could be discover actually fascinating is individuals who have been on these fad diets like, you realize, keto weight-reduction plan or paleo weight-reduction plan have been the worst offender of their organic age. The individuals who have been on keto weight-reduction plan the truth is have been three to 5 years older than their chronological age and the identical is true for paleo weight-reduction plan. It seems that people who find themselves on balanced weight-reduction plan, meaning they have been consuming their carbs however not lots however they have been consuming their regular carbs, they have been consuming their protein, they have been consuming their fats and so they have been consuming the protein, they have been way more balanced, have been really higher off biologically than slicing out the entire nutrient group utterly.
Katie: That is sensible, that we want the variability. And I’ve discovered increasingly as properly that I believe the simplistic model all of us discovered, hopefully discovered in class was about simply form of energy in, energy out. And I’ve heard it mentioned, you realize, our physique’s not a checking account. It’s a chemistry lab. And so, I now attempt to eat for maximal micronutrient and nutrient density in meals, not simply hitting or not hitting goal calorie ratios as a result of it’s a lot extra various and vital than that.
And what’s subsequent for Viome? I’m curious as a result of I do know you’re always doing analysis right here, and such as you mentioned, your aim is to deal with persistent illness in its entirety. So, what’s within the pipeline for you guys?
Naveen: Really, I discussed that subsequent take a look at we’re launching in June is a full physique intelligence. We’re launching a most cancers detect take a look at. And we’re making our dietary supplements and probiotics increasingly exact for each particular person since we make it for every particular person. We’re, you realize, attempting to do further exams now and our aim is to launch within the subsequent six months one other take a look at which is gonna be extra, like, a proteomics take a look at as a result of the issues we can’t see within the blood as a result of they’re produced someplace else. So, can we measure issues, you realize, the proteins for a Hashimoto illness? Can we measure issues like lipopolysaccharide binding protein that may predict when you have a leaky intestine by LBP, by CRP which really is completed within the liver? So, we’re going to have the ability to really measure further issues along with simply those that we’re measuring, and the extra data we are able to be taught, the higher suggestions we make. So, our hope is to proceed to launch these exams that give us higher and higher insights and meaning we are able to make increasingly exact advice for every particular person.
Final aim actually is to know…as you say, the human physique is a chemistry lab. We’ve got principally biochemical reactors in our physique. Your physique is a biochemical reactor. And that’s the factor folks want to know that the gene expression tells you what biochemistry is happening within the physique. And that’s a cause…and in reality, Viome is the one firm that does take a look at the gene expression as a result of there isn’t any different firm that has this expertise. And I believe individuals who have listened to your earlier podcast, we talked about, this explicit expertise got here out of Los Alamos Nationwide Lab the place they’d the laboratory for biodefense undertaking. And that’s the rationale nobody else can do it as a result of it took 10 years and multibillion {dollars}’ price of sources to develop this expertise. Sadly, we have been very lucky to have the ability to get the license to have the ability to use this expertise to assist the humanity get higher. And if our mission was merely to make cash, we’d not have been in a position to license this expertise, proper.
So, the very fact at present we’re merely targeted on making each single individual be higher. You recognize, our mission on day one was what if we may perceive the human biology at a molecular degree so we are able to forestall, diagnose early and remedy these persistent ailments together with most cancers and growing older? And I believe a whole lot of the individuals who have heard you and I discuss previously, you realize that I misplaced my dad to most cancers and that was one of many greatest motivator for me as a result of if I had began this firm half a decade earlier than I did, I may have probably saved my dad. And, you realize, having watched him undergo that ache or struggling by means of most cancers I spotted that despite the fact that I couldn’t save him, I may dedicate my life to saving everybody else. And that might be my means of letting him know that, you realize, I’m so pleased with what he…how he raised us as a toddler and giving us all the pieces we’ve so we’re in a position to save everybody else’s family members whether or not it’s from coronary heart illness or diabetes or melancholy, nervousness or most cancers.
And my hope actually is that in our lifetime we’ll completely eradicate most cancers from the human physique. And if I have been to make a prediction at present, I’ll let you know inside a decade I believe we’ll eliminate most cancers from the human physique.
Katie: That’s an enormous declare and I hope we’re on observe for that as properly. I’ve misplaced two prolonged members of the family within the final couple of months alone to most cancers in addition to a few of my grandparents. And it’s no secret that these are all nonetheless very a lot on the rise proper now and I’m positive the persistent stress of the final couple of years will not be serving to that drawback. So, I’m grateful that there are sources such as you, and I’ve performed Viome. I’m doing an up to date one proper now so I can report again with my outcomes on that. However I additionally am gonna be certain that…I do know you’ve supplied a reduction code for the Viome testing. In order that hyperlink might be within the present notes for you guys listening at wellnessmama.fm. Yow will discover the low cost code and the hyperlink on to it there. And to verify I respect your time, there’s a pair final questions I might like to ask you. The primary being if there’s a e-book or numerous books which have profoundly influenced your life. And in that case, what they’re and why?
Naveen: Yeah, so the e-book that actually influenced me…there’s a e-book by Clayton Christensen, you realize. I really like the person and I noticed him earlier than he died. The e-book he wrote, “How Will You Measure Your Life?” And to me it was such a profound e-book which tells you that you must be 100% sincere. You can’t be 99% sincere as a result of as soon as you are taking a step down of this honesty, it’s a slippery slope and there’s no stopping it. When you make an exception to one thing, there’s simply no going again however there’ll all the time be another excuse to make an exception. And so, you must focus your self to by no means, ever compromise in your ideas that you simply stand for. And that was simply completely a wonderful e-book I learn.
You recognize, the e-book that additionally…I imply, clearly I wrote a e-book referred to as “Moonshots” that’s actually about making a mindset of abundance fairly than a mindset of shortage. And the basic perception that I’ve is that there’s nothing that people usually are not able to doing if we really get our mindset to consider we are able to. So, any time when somebody says, “I can or I can’t,” it’s true as a result of it’s as much as them to resolve whether or not they can or they will’t. That after you consider one thing is not possible, it turns into not possible for you and nobody else. And so, you’re utterly in management. The one factor you may’t do is what you may’t think about. All the pieces else is feasible.
Katie: I really like that. I do know you and I each increase our youngsters with that mindset and yours are older and doing superb issues out on the earth already and mine are at first phases of that. And lastly, what parting recommendation would you want to go away with the viewers at present? Could possibly be associated to one thing we’ve talked about or fully unrelated.
Naveen: I might say dream so huge that individuals assume you’re loopy. Meaning by no means let somebody let you know you can’t do it. Fall in love with your self as a result of the day you fall in love with your self is the day the world will fall in love with you. Loving your self will not be about being self-conceited. Loving your self is about not in search of another person’s approval to do the issues that imply lots to you. Comply with your coronary heart, comply with your intestine, hearken to your intestine and comply with what it tells you. Discover a goal in life. When you discover a goal in life, you’ll by no means ever assume it’s work. I stand up daily at 4 a.m., and that’s my recommendation to everybody. Everytime you stand up within the morning, when you’re not leaping out of the mattress, you need to give up what you’re doing as a result of that’s not your calling, as a result of once you discover your calling, you’ll not be mendacity down within the mattress. You soar out of the mattress with pleasure wanting to resolve that drawback.
And, Katie, I simply need to reiterate, I met your children and I do know I bear in mind the oldest one and I gave him the Moon rock at the moment. I’m telling you your children are going to really transfer this humanity ahead. You’re elevating these youngsters with the mindset that all the pieces they need to do, they will. And each mom who’s listening to it simply ought to know that parenting is definitely very counterintuitive. And, Katie, you and I’ve talked about it a whole lot of instances. Like, after we increase our kids, we inform them, “Our love for you is unconditional however our approval will not be.” And what meaning is just is that we’ll all the time love you, we’ll all the time be there for you, however I’m not gonna let you know I’m pleased with you except you do issues that make us pleased with you. And that’s actually the factor about telling the kids that their success won’t ever be measured by how a lot cash they’ve within the financial institution. It will likely be measured by what number of lives they enhance. And the humility is an indication of success as a result of when you nonetheless have iota of conceitedness left in you, meaning you’re nonetheless attempting to show one thing to your self or another person. And humility tells you now not have to try this, proper. And that could be a true signal of success. And all I can say is I’m so pleased with each one in all your youngsters, Katie. And I can’t await them to develop up and truly do issues that may make our kids’s and grandchildren’s life higher.
Katie: Oh, thanks a lot for saying that. Individuals who don’t know, you and I first met and actually bonded over really parenting earlier than we ever talked about well being. And we share that similarity. I inform my children daily, “I really like you unconditionally and there’s nothing you ever should do to earn my love and there’s nothing you possibly can ever do that might take away from my love.” However you’re proper. Additionally, I would like that, like, their pleasure to come back from inside, like…and I inform them typically, “You could really feel actually pleased with how onerous you labored and you have to…” As a result of I would like them to have that inside them and that self-love.
And for this reason I’m so grateful each single day that I get to speak to our viewers that’s listening at present of mothers, as a result of I believe mothers have such a tremendous distinctive skill to actually shift the way forward for humanity by how we mum or dad our youngsters and by serving to kind these future leaders. And for individuals who aren’t already aware of you, I might encourage you to hearken to our previous interview since you inform extra of your story in that one and also you very a lot stroll the stroll of this, of getting constructed all these superb issues after which now serving to your children on their life journeys and your spouse in her personal proper is unbelievable as properly. So very grateful to your complete household and for all that each one of you’re doing on the earth and to your time at present. I understand how busy you’re and I’m so grateful you took the time to be right here.
Naveen: Oh, Katie, it’s all the time an honor and a pleasure to be talking with you, and I’m trying ahead to our subsequent dialog.
Katie: And thanks, as all the time, to all of you for listening and sharing your most beneficial sources, your time, your vitality, and your consideration with us at present. We’re each so grateful that you simply did. And I hope that you’ll be a part of me once more on the subsequent episode of the “Wellness Mama” podcast.
When you’re having fun with these interviews, would you please take two minutes to go away a score or evaluate on iTunes for me? Doing this helps extra folks to search out the podcast, which suggests much more mothers and households may gain advantage from the data. I actually admire your time, and thanks as all the time for listening.
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